67th Annual Meeting Abstracts
Is Bladder Cancer Severity or Long Term Outcomes After Radical Cystectomy Affected By Body Mass Index?
*Andrew Harris, *Phillip Mucksavage, *Meredith Bergey, Bruce Malkowicz
Hospital of the University of Pennsylvania, Philadelphia, PA
Introduction: Obesity is a growing problem in the developed world. Although obesity has been shown to influence many types of cancer, there is very little data examining the effect of body mass index (BMI) on bladder cancer. We evaluated the effects of BMI on pathologic bladder cancer stage in patients undergoing radical cystectomy for bladder cancer.
Materials and Methods: The clinical and pathologic data on 356 patients available in a prospectively maintained radical cystectomy database were reviewed with respect to BMI. Patients were divided into the WHO categories of normal weight (BMI <25 kg/m2), overweight (BMI 25 kg/m2 to 29.9 kg/m2 and obese (BMI > 30 kg/m2). Analysis was performed using Chi squared analysis, Kaplan-Meier survival curves, and log-rank test. Results: Overall, 110 patients (27%) had a normal weight, 142 (35%) overweight, and 84 (21%) obese. Patients were divided into lower pathological stages (less than or equal to pT2,194 patients) and higher pathological stage (higher than pT2, 162 patients). When BMI was compared to higher and lower pathologic stage, there was no significant difference (p=0.19). Kaplan-Meier survival analysis showed a median overall survival in normal weight individuals to be 42.7 months, 44.7 months in overweight individuals, and 47.3 months in obese individuals, which was not significant (p=0.53).
Conclusions: There is little or no data concerning the effects of obesity on outcomes after radical cystectomy. This data suggests obesity may not play a role on the severity of bladder cancer or long term outcomes after radical cystectomy.
