2008 Annual Meeting Abstracts
Relative Survival after Surgical Treatment of Localized RCC_A S.E.E.R. Analysis: Is Age Important?
Benjamin J Scoll, Yu-Ning Wong, Brian L Egleston, David A Kunkle, Ismail R Saad, Robert G Uzzo
Fox Chase Cancer Center, Philadelphia, PA
Introduction: Recent data report that age may be a significant independent prognostic variable following treatment for RCC. We analyzed data from the Surveillance Epidemiology and End Results (SEER) database to calculate relative survival of patients surgically treated for localized RCC as related to tumor size and patient age at treatment.
Methods: The SEER database was used to create a cohort of patients treated surgically for localized, node negative RCC from 1988 to 1997. Patients were stratified and analyzed by age and tumor size. Three- and five-year relative survival rates were calculated using SEER-Stat software.
Results: Review of the SEER database identified 8578 patients as having undergone definitive surgery for pathologically localized RCC. Three- and five-year relative survival rates are presented in the table. We did not identify scientifically meaningful trends in 3- and 5-year relative survival across age groups for those with small (<4 cm) or large (>7 cm) tumors. However, a scientifically meaningful trend towards lower relative survival was demonstrated with increasing age in patients with medium size tumors (4-7 cm).
Conclusions: This data suggests that advanced age may be related to worse outcomes in patients with localized RCC tumors between 4 and 7 cm. The cause of this observation warrants further investigation.
Relative Survival (RS) in RCC by Age and Tumor size | Age 40-49 | Age 50-59 | Age 60-69 | Age 70-79 | Age 70-79 |
| < 4 cm (n) | 419 | 654 | 853 | 718 | 718 |
| % 3-year RS | 97.4 | 96.0 | 96.5 | 97.8 | 97.8 |
| % 5-year RS | 95.5 | 94.2 | 94.2 | 96.6 | 96.6 |
| 4-7 cm (n) | 616 | 923 | 1086 | 985 | 985 |
| % 3-year RS | 97.6 | 96.0 | 93.9*† | 91.8*†† | 91.8*†† |
| % 5-year RS | 95.5 | 91.2*†† | 90.3*†† | 85.8*†† | 85.8*†† |
| >7 cm (n) | 402 | 530 | 524 | 411 | 411 |
| % 5-year RS | 92.6 | 88.5 | 91.0 | 90 | 90 |
| % 5-year RS | 88.6 | 83.6† | 86.5 | 83.8 | 83.8 |
* p<0.05 for comparison with 30-39 group
† p<0.05, †† p<0.01 for comparison with 40-49 group
