|
|
 |
| |
2008 Annual Meeting Abstracts
Characterization Of Extraprostatic Extension Sites And Its Relationship To Surgical Margins Following Robot Assisted Radical Prostatectomy
Douglas E Sutherland, M. Katayoon Rezaei*, Arnold M. Schwartz*, Harold A. Frazier, II, Jason D. Engel, Nikki Mourtzinos*, Mark Hong, Brian Linder*, Fernando J Bianco, Jr.
George Washington University, Washington, DC
Introduction: Extraprostatic extension (EPE) of prostate cancer is of prognostic importance following prostatectomy. We sought to characterize the location of EPE in a RALRP cohort, and determine the relationship between EPE and positive surgical margins (PSM).
Methods: Men treated between 2004 and 2007 were considered. Specimens with evidence of EPE or a PSM were reviewed pathologically to determine the anatomic locations of PSMs and EPE, and categorized as anterior (A-EPE) or posterolateral (PL-EPE) to the urethra. Multifocality of EPE (MF-EPE), PSM, and PSM at EPE was determined. Chi-square tests and t-tests were applied.
Results: A total of 568 patients had RALRP during the study period, 81% were clinical stage T1c. Median age and PSA for the cohort was 59.9 and 5.4, respectively. Overall, 97 patients were identified with EPE, established EPE in 68 (12%), focal in 29 (5%). Multiple foci were present in 74 (76%). There were 82 (14%) and 30 (5%) instances of PL-EPE and A-EPE, respectively. For the 428 T1c patients, exclusive A-EPE or PL-EPE and the presence of both was seen in 10 (2%), 40 (9%) and 14 (3%), p<0.001. Of 116 PSMs identified, 8% (n=9) occurred at sites of EPE and were equally distributed between clinical stage T1c and >T2 patients.
Conclusions: EPE and MF-EPE were found to be approximately two- and four-times more common on the posterolateral prostate surface, and were related to clinical stage. 92% of the PSM occurred without evidence of EPE at the margin site.
|
|
| |
|
|
| |
|
|
|
|
