|
|
 |
| |
Back to MAAUA Scientific Program
Morbidity of Hemorrhagic Cystitis Related to Radiation Therapy for Prostate Cancer
Clinton W. Collins, Bella Gabice*, B. Mayer Grob, Adam P. Klausner
Virginia Commonwealth University Health System, Richmond, VA
Introduction: The incidence of hemorrhagic cystitis post-radiation therapy for prostate cancer has been quoted as 1.5 to 2%. Our objective is to determine the impact of radiation therapy on the morbidity of hemorrhagic cystitis.
Methods: Electronic medical records were queried for admissions to our tertiary care center with diagnosis of hematuria from October 2004 to January 2007. Data recorded included presence of hematuria, history of radiation therapy for prostate cancer, need for continuous bladder irrigation (CBI) or transfusion, and use of anticoagulants on admission.
Results: Seventy-five patients were admitted secondary to hematuria. Fifty-six were non-irradiated and nineteen were irradiated. Eight of nineteen irradiated patients were transfused versus nine of fifty-six non-irradiated patients (42.1 vs. 16.1%. respectively, P = 0.0191). Twelve of nineteen irradiated patients required CBI versus eighteen of fifty-six non-irradiated patients (63.2 vs. 32.1%, respectively, P = 0.0171). Twelve of forty patients using anticoagulants required transfusion versus five of thirty-five without anticoagulant use (30 vs. 14.3%, respectively, P = 0.1049).
Conclusions: There was a statistically significant difference in morbidity in irradiated patients compared with non-irradiated patients. Irradiated patients were more likely to need a transfusion (42.1% vs. 16.1%) and CBI (63.2% vs. 32.1%) than non-irradiated patients. Irradiated patients represented 25.3% of admissions but 47% of those transfused and 40% of those requiring CBI. Patients considering radiation therapy for prostate cancer should be counseled that while the overall incidence of hemorrhagic cystitis is low, when present, it carries a significant risk of transfusion and bladder irrigation.
Back to MAAUA Scientific Program
|
|
| |
|
|
| |
|
|
|
|
