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Rapidly Developing Fluoroquinolone Resistance of Common Uropathogens
Gerboc Jason, Phillip C. Ginsberg, Michael J Metro, Richard C. Harkaway
Albert Einstein Medical Center, Philadelphia, PA

Introduction: To investigate and report on the growing antimicrobial resistance of common uropathogens to fluoroquinolone and other antibiotics.
Methods: We reviewed our institutions’ antibiograms, which were available for the years 2002 through 2005, for changes and trends in susceptibility and resistance patterns for common uropathogens such as Klebsiella pneumoniae, Proteus mirabilis and Pseudomonas aeruginosa with emphasis on the most common cause of urinary tract infections, Escherichia coli.
Results: Forty-one percent of all Escherichia coli isolates were resistant to fluoroquinolones in 2005, up from just 22% in 2002. The resistance of Escherichia coli to fluoroquinolones has increased by nearly 20% in the last four years. The percentage increase in yearly incidence of Escherichia coli resistance has grown in each successive year. The largest gains in resistance in all isolates were for fluoroquinolone antibiotics versus other commonly used antibiotics. The resistance of Escherichia coli and other organisms causing UTI has increased to fluoroquinolones as well as amoxicillin/ampicillin and TMP/SMX.
Conclusions: There is growing resistance of many organisms responsible for both community acquired and nosocomial urinary tract infections to fluoroquinolone antibiotics. Fluoroquinolones are often used for antimicrobial prophylaxis for urologic procedures as well as empiric treatment for UTIs by both urologists and non-urologists.

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