|
|
Back to Scientific Program
Back to Annual Meeting
Correlation Between Known Upper Tract Tumor and Bladder Cytology
Eric Nelson*, Jeffrey Tomas*, Marluce Bibbo*, Demetrius Bagley
Thomas Jefferson University, Philadelphia, PA
Introduction: Bladder urine cytologies are used to aid in diagnosis and surveillance of patients with urinary tract transitional cell carcinoma (TCC). We investigated whether intraoperative bladder cytology was accurate in reflecting the upper tract neoplasm.
Methods: We performed a retrospective analysis of 39 patients with confined upper tract TCC without bladder TCC from 1999 to present. Bladder and upper tract cytology specimen results were categorized into five groups: negative, reactive, atypical, suspicious and malignant. Upper tract cytology specimens were divided into three groups: initial/aspirate, biopsy and post-biopsy/post-resection.
Results: Thirty-nine patients and 66 endoscopic procedures were reviewed. Upper tract TCC was documented by either positive cell block biopsies or direct visualization of papillary lesions. Bladder urine cytology was positive for malignant cells in 13 cases (19.7%), suspicious in 5 cases (7.58%), atypical in 39 cases (59.09%), reactive in 3 cases (4.55%) and negative in 6 cases (9.09%). Of the 13 positive cytologies, 10 had cell block biopsies available: five (50%) were high grade and five (50%) were low grade lesions. Of the 56 aspirates from the upper tract, 27 (48%) were positive for malignant cells. Of the 51 biopsy specimens, 36 (70.59%) were positive and of the 57 post-biopsy specimens, 39 (68.42%) were positive.
Conclusions: Bladder cytology is poor at positively identifying patients with known upper tract disease. Accuracy is similar for high and low grade lesions. Upper tract cytology specimens are overall more accurate in reflecting upper tract disease, with biopsy and post-biopsy specimens having greater accuracy than initial aspirates.
Back to Scientific Program
Back to Annual Meeting
|
|
