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Female Sexual Dysfunction In Patients With Interstitial Cystitis: Evaluation Of the Use Of Anti-Depressants
Stanley Zaslau, Can Talug, Dale Riggs*, Barbara Jackson*, Stanley J. Kandzari
West Virginia University, Morgantown, WV

Introduction: The presence of female sexual dysfunction (FSD) in patients with interstitial cystitis (IC) is significant and well documented. The authors report herein the data on 1300 subjects indexed by the use of anti-depressant medications and compare the degree of FSD associated with the disease.
Methods: Domain values were obtained by using the Female Sexual Function Index (FSFI). This 19-item questionnaire evaluated FSD in the following six domains: desire, arousal, lubrication, orgasm, satisfaction, and pain. This study used the FSFI with the additional indicator of current medications. Each question in the survey was targeted to a specific indicator of FSD and the answers were rated on a Lickert scale. Data were analyzed on an item-for-item basis and by the six domains of FSD for these subjects. The respondents were sorted by the use of anti-depressant medications (n=465) and the absence of such medication (Control, n=835).
Results: The table below compares these data with the two comparison groups across the six domains measured by the FSFI.
Conclusions: The use of anti-depressant medication resulted in significantly higher levels (p<0.001) of FSD in patients suffering from IC. Whether this difference is due to the depression or the medication remains to be determined.

DOMAIN	Anti-Depressants N=465 Mean + S.D.	Control Data N=835 Mean + S.D.	ANOVA p Value
Desire	1.91 + 0.08	2.13 + 0.12	p<0.001
Arousal	2.21 + 0.14	2.43 + 0.14	p<0.001
Lubrication	2.09 + 0.38	2.34 + 0.51	p<0.001
Orgasm	2.19 + 0.10	2.44 + 0.15	p<0.001
Satisfaction	2.41 + 0.32	2.50 + 0.34	p<0.001
Pain	1.59 + 0.13	1.84 + 0.12	p<0.001

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