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Does Submission Of Prostate Biopsies In A Site Specific Manner As Compared To Submitting Labeled Grouped By Side Only Affect Margin Rates At Radical Prostatectomy
Eric Richter1, Joel Moncur*1, Isabel Sesterhenn2, David G McLeod1
1Walter Reed Army Medical Center, Washington, DC;2Armed Forces Institute of Pathology, Washington, DC
Introduction: When prostate biopsy specimens are sent for pathologic examination, cores may be submitted individually labeled by specific location, or grouped, labeled by side only. Site specific labeling requires more labor and cost. We sought to determine if the added labor and cost can be justified by decreasing positive margins at prostatectomy. Additionally we wanted to determine if the location of positive margin or extracapsular extension could be predicted by location of positive biopsy.
Methods: The charts of 138 patients (69 grouped, 69 site labeled) treated for prostate cancer by radical prostatectomy were reviewed for the presence of positive margins. For patients who were diagnosed by biopsies processed by site specific labeling, the location of positive margin was determined and correlated to the location in which there was cancer present in biopsy cores.
Results: Using Chi-square analysis, we examined the association of margin status (positive versus negative) by type of biopsy (labeled versus grouped). No statistically significant relationship was noted (Chisq = 0.419, df = 1, p = 0.52). We also examined whether pathological grade (pT1-pT2 versus pT3-pT4), clinical stage (cT1-cT2 versus cT3-cT4), or biopsy grade (2-6, 7-10) was associated with type of biospy; again, no statistically significant relationship emerged.
Conclusions: No difference exists with regard to margin status when prostate biopsy specimens are submitted labeled in a site specific manner when compared to labeling grouped by side only. The additional labor and cost of submitting biopsies labeled in a site specific manner may not be justified.
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